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The Journal of Nuclear Medicine Vol. 15 No. 9 814-817
© 1974 by Society of Nuclear Medicine
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A Quick Method for Calculation of the Vascular Mean Transit Time

M. E. Phelps and J. O. Eichling

Washington University School of Medicine, St. Louis, Missouri

Correspondence: For reprints contact: Michael E. Phelps, Div. of Radiation Sciences, Mallinckrodt Institute of Radiology, Washington University School of Medicine, 510 S. Kingshighway, St. Louis, Mo. 63110.

ABSTRACT

A simple, quick, and accurate method for the determination of mean transit time ({tau}) from an arterial bolus injection of a radioactive non-diffusible tracer was derived. In this method the mean transit time is simply equal to the width, in time, of the vascular clearance curve when its height has been reduced to 1/e of the maximum value. Using radioactive C15O-hemoglobin as a vascular tracer, {tau} was calculated by this method ({tau}eq and compared with a direct integration method ({tau}p) with a planimeter for 52 cerebral {tau} measurements in rhesus monkeys and humans. The values of {tau} ranged from 1.4 to 10.7 sec. The regression analysis of the values of {tau} calculated by the two methods gave the equation {tau}eq = 1.007 {tau}p + 0.001, r = 0.999, p < 0.0001. The method suggested in this work requires a single semilog plot and takes less than a minute whereas the planimeter method requires a semilog and linear plot and takes 10–15 min to calculate {tau}. There was no demonstrable decrease in accuracy using the suggested method when comparisons were made to the direct integration method (above equation).






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Copyright © 1974 by the Society of Nuclear Medicine.