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An Efficient Method for Fractional Labeling of Microspheres

Loma Linda University Medical Center, Loma Linda, California

Correspondence: For reprints contact: Howard C. Wieland, Nuclear Medicine Dept., Loma Linda University Medical Center, Loma Linda, Calif. 92354.

ABSTRACT

The introduction of human albumin microspheres (HAM) is a significant advance in carrier-protein technology for the study of capillary perfusion. However, the recommended labeling procedure is an expensive and inefficient method for the utilization of microspheres and technetium. A procedure is outlined for the fractional labeling of HAM with technetium. This provides a simple, efficient, and economical use of microspheres and technetium allowing for high specific activity particles. It is particularly applicable to nuclear medicine departments with a relatively small patient load.