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Radiozinc Uptake and Scintiscanning in Prostatic Disease

Hammersmith Hospital and Royal Postgraduate Medical School, London, England

Correspondence: For reprints contact: G. D. Chisholm, Urological Unit, Dept. of Surgery, Hammersmith Hospital, London W12 OHS, England.

ABSTRACT

Zinc radioisotopes have been used to study the tissue distribution of zinc in the rat and human and to obtain scintigraphic images of the prostate in man. Two hours after administration of ⁶⁵Zn into the rat most of the radioactivity was found to be in kidney, liver, pancreas, and prostate. However, after 20 hr the uptake of ⁶⁵Zn by kidney, liver, and pancreas decreased whereas the uptake of radioactivity in the prostate, seminal vesicle, and bone continued to increase. The uptake of ⁶⁵Zn by prostate, bladder, and muscle was measured in patients with benign prostatic hypertrophy (BPH) by injecting ⁶⁵Zn at different periods prior to open prostatectomy. There was a continuous increase in the concentration of ⁶⁵Zn by the prostate whereas the concentration in muscle remained constant. The greatest contrast between prostate and surrounding muscle was found to be between 12–24 hr after administration. Using ⁶²Zn, prostate images were obtained in patients with BPH and carcinoma of the prostate. The scintiscan showed only an indefinite outline of the prostate in BPH. The results demonstrate the limitations of these radioisotopes in the study of prostatic disease.