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Radioisotopes in Preliminary Screening of Cervical Cancer

Hahnemann Medical College and Hospital, Philadelphia, Pennsylvania
Affiliated Medical Research, Inc., Princeton, New Jersey

Correspondence: For reprints contact: John H. Nodine, Hahnemann Medical College and Hospital, Philadelphia, Pa. 19102.

ABSTRACT

In an attempt to automate screening for cervical cancer, the nuclear changes observed cytologically were compared with radioactive nuclear stains in order to determine the different cellular uptakes of radioactive material by normal cells and cancer cells. Among 205 normal women, approximately 15% of false positives occurred by this technique. With invasive carcinoma, the uptake was elevated in all 25 studied. In addition, a higher percentage of patients showed elevated uptakes with cervical dysplasia. The number of cases with carcinoma in situ (four) studied is insufficient for definitive conclusions. The method is adaptable to complete automation and appears economically sound as a prescreening technique. It is recommended that the technique be applied in a much larger series during routine screening for cervical cancer.