HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Jones, R. H. Articles by Sabiston, D. C. Search for Related Content PubMed PubMed Citation Articles by Jones, R. H. Articles by Sabiston, D. C.

Evaluation of ¹³³Xe Techniques for Measurement of Regional Ventilation

Duke University Medical Center, Durham, North Carolina

Correspondence: ¹ For reprints contact: Robert H. Jones, Dept. of Surgery, Duke University Medical Center, Durham, N.C. 27710.

ABSTRACT

Despite widespread clinical use of radioactive gases for evaluation of regional ventilation, little evidence is available for evaluating the accuracy of these techniques. Excised dog lung preparations with controlled perfusion and ventilation were used in the present study to compare known ventilation to the rate of alveolar clearance of ¹³³Xe. Xenon-133 was administered by three different methods in separate groups of determinations. Perfusion of the excised lung preparations with blood collected by exsanguination permitted assessment of ventilation by a technique similar to the injection of ¹³³Xe dissolved in saline in patients. The standard error of the distribution of ventilation measured by this approach in 17 determinations was 4.1%. In the second group of experiments, ¹³³Xe in air was administered by a single inhalation and the washout of ¹³³Xe compared with the known distribution of ventilation with a standard error of 5.1%. In a third group of determinations, the lung preparations were ventilated with ¹³³Xe mixed in air until counts reached equilibrium and the rate of ¹³³Xe clearance during subsequent air breathing was determined. The distribution of ventilation measured by this approach demonstrated the greatest accuracy of all techniques examined with a standard error of 2.6%. In addition, the actual minute volume was compared with absolute slope values of ¹³³Xe clearance in this single lung preparation and the correlation coefficient of 0.96 further substantiates the inherent accuracy of ¹³³Xe washout for assessment of regional ventilation.