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A Rapid Method for Measurement of Fractional Intestinal Absorption of Calcium

Hôpital Necker, Paris, France

Correspondence: ¹ For reprints contact: J. Chanard, Dept. de Nephrologie, Service d'Etudes Métaboliques, Hôpital Necker, 161 rue de Sèvres, 75015 Paris, France.

ABSTRACT

A single method for fractional intestinal calcium absorption (FCaA) measurement on plasma samples is proposed. FCaA is measured within a time interval of less than 8 hr using only one isotope successively injected intravenously and ingested 2 hr later. Assuming that plasma disappearance of the intravenously administered dose is identical to that of the absorbed oral dose we have verified that: (A) the absorption of the radioactive oral dose was achieved within 4 hr, (B) the log curve of plasma radioactivity obtained after total absorption of the oral dose is a straight line parallel to that obtained after the intravenous dose. This corresponds to the "exchangeable calcium expanding pool" model.

FCaA was measured in 60 subjects. FCaA was 58.9% ± 3.7 (mean ± s.e.m.) in controls, 90.7% ± 4.7 in primary hyperparathyroidism, 79.3% ± 4.8 in idiopathic hypercalciuria, 81% in Paget's disease, and 35.8% ± 2.6 (p < 0.001) in chronic renal failure treated conservatively. Following hemodialysis FCaA was transiently increased to 50.6% ± 2.5 (p < 0.001) when performed 10–12 hr after the hemodialysis run (calcium dialysate concentration = 7 mg%).

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