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Distribution of ¹⁴C and ³H-Streptozotocin in Dogs and Toadfish

University of Michigan Medical Center, Ann Arbor, Michigan

Correspondence: ¹ For reprints contact: William H. Beierwaltes, Div. of Nuclear Medicine, University of Michigan Medical Center, Ann Arbor, Mich. 48104.

ABSTRACT

Since streptozotocin shows a highly specific action on the function of islet cell tissue of the pancreas, a tissue distribution study of the labeled compound was completed to evaluate possible concentration of streptozotocin in the beta cells. Ten dogs and 46 toadfish were injected intravenously with ¹⁴C- or ³H-labeled streptozotocin. Tissue distribution studies were completed in dogs at 1, 2, 3, 4, 6, or 24 hr and in toadfish at 10 min, 1, 2, 3, 4, 6, or 24 hr.

No selective concentration of labeled streptozotocin occurred in dog pancreas at any time interval. Islet cells of the toadfish also failed to show specific concentration of streptozotocin. There was no significant difference in the pattern of distribution and excretion between both labeled compounds.