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Quality Control of ^99mTc-DTPA by Double-Tracer Clearance Technique

The Johns Hopkins Medical Institutions, Baltimore, Maryland

Correspondence: For reprints contact: F. Hosain, Div. of Nuclear Medicine, 615 N. Wolfe St., Baltimore, Md. 21205.

ABSTRACT

Sn-DTPA kits were evaluated by the biological behavior of ^99mTc-DTPA preparations as an index of the quality of the radiopharmaceutical. Plasma clearance and urinary excretion were determined in dogs along with a second tracer such as ^113mIn-DTPA. Glomerular filtration rates were compared for the two tracers. The results could be divided into two categories corresponding to good and deteriorated ^99mTC-DTPA preparations. A good product behaved kinetically in a manner almost identical to that of the second tracer. Deteriorated products showed (A) reduced urinary excretion, (B) higher plasma activity after 2 hr, (C) appearance of a third component in the plasma clearance curves, and (D) decrease in the calculated values of glomerular filtration rate.