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Effects of Capillary Blockade with ^99mTc-Iron Hydroxide: A Histopathologic Study

Harvard Medical School and Peter Bent Brigham Hospital, Boston, Massachusetts

Correspondence: For reprints contact: M. A. Davis, Dept. of Radiology, Harvard Medical School, 50 Binney St., Boston, Mass. 02115.

ABSTRACT

Twenty-six mice injected with ^99mTc-ferrous hydroxide macroaggregates (Tc-FHMA) were sequentially sacrificed over a 40-week period. Histologic sections of lung tissue stained for iron or with hematoxylin-eosin were prepared. Microscopic examination revealed changes in particle size and location of the FHMA with time after administration. Several mechanisms of clearance such as aggregate breakup, particle dissolution, and cellular phagocytosis were evident. The major finding was the complete absence of pathologic lesions that could be attributed to the long-term residence of Tc-FHMA in the pulmonary capillaries.