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⁶⁷Ga-Citrate Imaging in Untreated Primary Lung Cancer: Preliminary Report of Cooperative Group

Frank H. DeLand, Bertram J. L. Sauerbrunn, Charles Boyd, Robert H. Wilkinson, Jr., Ben I. Friedman, Mohammed Moinuddin^*, David F. Preston and Ralph M. Kniseley

University of Florida College of Medicine, Gainesville, Florida
VA Hospital, Washington, D.C.
University of Arkansas School of Medicine, Little Rock, Arkansas
Duke University Medical Center, Durham, North Carolina
University of Tennessee College of Medicine, Memphis, Tennessee
University of Kentucky Medical Center, Lexington, Kentucky
Oak Ridge Associated Universities Medical Division, Oak Ridge, Tennessee

ABSTRACT

An interinstitutional cooperative study has been undertaken to evaluate ⁶⁷Ga as a tumor-localizing agent. A uniform protocol and computer handling of data have been used. In 172 untreated patients with primary lung cancer, approximately 84% had one or more sites demonstrated on scanning with ⁶⁷Ga; 80% of individual lesions histologically verified had positive scans. It is occasionally possible to detect rather small lesions and, conversely, on occasion to miss some large lesions (5 cm or larger). Negative scans were obtained in 16% of lesions histologically proven. In the present analyses, rates of detection differ somewhat according to histologic type but not strikingly. With further developments in tumor-localizing agents and instruments, the agent may eventually be useful in the initial diagnostic workup of suspected lung carcinoma in certain clinical situations. As a single screening scan procedure, it should prove helpful in assessing the extent of disease before surgery or other type of therapy.

FOOTNOTES

For reprints contact: Administrative Office, Medical Division, Oak Ridge Associated Universities, P.O. Box 117, Oak Ridge, Tenn. 37830.

^* Present address: Baptist Memorial Hospital, Memphis, Tenn.

Present address: University of Kansas Medical Center, Kansas City, Kans.

Present address: International Atomic Energy Agency, Vienna, Austria.