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⁶⁷Ga-Citrate Imaging in Untreated Malignant Lymphoma: Preliminary Report of Cooperative Group

Marshfield Clinic, Marshfield, Wisconsin
University of Miami School of Medicine, Miami, Florida
Vanderbilt University School of Medicine, Nashville, Tennessee
University of Louisville School of Medicine, Louisville, Kentucky
USPHS Hospital, Baltimore, Maryland
Oak Ridge Associated Universities Medical Division, Oak Ridge, Tennessee

ABSTRACT

An interinstitutional cooperative study has been undertaken to evalute ⁶⁷Ga as a tumor-localizing agent. A uniform protocol and computer handling of data have been used. In 167 cases of previously untreated lymphoma (other than Hodgkin's disease) scanned with ⁶⁷Ga, approximately 78% had one or more positive sites demonstrated on scan. Of histologically proven sites, 51% had a positive scan and with those sites apparent or suspected but not biopsied, 54% were positive. Thus a negative scan does not exclude the presence of disease. A low "false-positive" rate was encountered; if a lesion is demonstrated by scan, it is highly likely that disease is present. Disease, unsuspected or believed absent, was first known at the time of scan in 28 sites. An additional 42 positive scan sites as yet unconfirmed by other evidence may also represent lesions discovered de novo by ⁶⁷Ga. The percent of positive scans is highest in the thorax. Histiocytic types, including mixed cell types, of lymphoma have higher rates of positive scans than lymphocytic types. Overall, the rate of positive scans is lower in lymphoma than in Hodgkin's disease.

FOOTNOTES

For reprints contact: Administrative Office, Medical Division, Oak Ridge Associated Universities, P.O. Box 117, Oak Ridge, Tenn. 37830.

^* Present address: International Atomic Energy Agency, Vienna, Austria.