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Use of ^99mTc-DTPA for Measuring Gastric Emptying Time

University of Iowa, School of Medicine, Iowa City, Iowa

Correspondence: For reprints contact: Tapan K. Chaudhuri, Nuclear Medicine, University of Iowa, School of Medicine, Iowa City, Iowa 52242.

ABSTRACT

A rapid and easy isotopic method for measuring gastric emptying time (GET) is described. It involves the use of ^99mTc-diethylenetriamine-pentaacetic acid (DTPA) and a gamma camera with a computer. Results of animal experiments and 24 studies in 8 normal volunteers are presented. The radiopharmaceutical is neither absorbed from nor adsorbed to the stomach in any significant amount. Our experimental data show less than 1% absorption and less than 1% adsorption of the compound in 30 min. The mean gastric emptying T_1/2 for a liquid meal in normal subjects was found to be 12 ± 3 min. Since ^99mTC-DTPA fulfills the criteria as an ideal agent for measuring GET and the technique is noninvasive with reproducible results, it may have a potential clinical use.

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