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Evaluation of an Improved ^99mTc-Stannous Aggregated Albumin Preparation for Lung Imaging

Baylor College of Medicine and St. Luke's Episcopal-Texas Children's Hospitals, Houston, Texas

Correspondence: For reprints contact: Linda A. Monroe, Dept. of Radiology, Nuclear Medicine Section, Baylor College of Medicine, 1200 Moursund, Houston, Tex. 77025.

ABSTRACT

An improved preparation of ^99mTc-labeled stannous aggregated albumin for lung imaging has been evaluated. The new kit consists of a vial of frozen human serum albumin aggregates which is labeled by a simple, rapid procedure with an efficiency consistently greater than 97%. Particle size distribution is excellent with 83% of particles having a diameter of 10–60 microns. No significant changes in particle size range or labeling efficiency were observed in kits which were refrigerated at 4°C up to 4 weeks compared with kits kept frozen. The quality of lung images was excellent and no adverse reactions were observed in a series of 50 patients with a variety of pulmonary disorders.