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Alterations in Tissue Distribution of ^99mTc-pertechnetate in Rats Given Stannous Tin

Donner Laboratory, University of California, Berkeley, California

Correspondence: For reprints contact: James McRae, Donner Lab., University of California, Berkeley, Calif. 94720.

ABSTRACT

A dose of 8 mg Sn(II)/kg produces significant mortality and gross kidney damage in the rat. The tissue distribution of ^99mTc-pertechnetate is altered in rats which have previously received Sn(II). Minimal changes are noted with a dose of 0.02 mg Sn(II)/kg. It should be noted that most kits for human use contain less than 1 mg of Sn(II) per kit and result in a dose less than 0.007 mg Sn(II)/kg. Changes are still present 13 weeks after a dose of 8 mg Sn(II)/kg. It is apparent that the effects of Sn(II) on ^99mTc-pertechnetate are not limited to in vitro reaction. The alterations in tissue distribution of ^99mTc.pertechnetate are most likely due to the chemical reduction and fixation of the ^99mTc-pertechnetate to tissue components due to the continuing presence of Sn(II) in vivo.