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Comparative Myocardial Uptake of Intravenously Administered Radionuclides

University of California, San Diego
School of Medicine, La Jolla, California

Correspondence: For reprints contact: Heinrich R. Schelbert, Div. of Nuclear Medicine, University Hospital, 225 W. Dickinson St., San Diego, Calif. 92103.

ABSTRACT

The myocardial and blood clearance rates and the myocardium-to-blood ratios for radiopharmaceuticals such as ⁴³K, ⁸⁶Rb, ¹²⁹Cs, radioiodinated oleic acid, ²⁰³Pb, ⁶⁹Zn, and ^99mTcO₄^– as a function of time were compared in rats. Attempts were made to alter these parameters by various pharmacological and dietary interventions. While ⁶⁹Zn, ²⁰³Pb, and ^99mTcO₄^– showed ratios below or only little greater than 1, ⁴³K, ⁸⁶Rb, and ¹²⁹Cs reached myocardial concentrations about 27 times higher than their corresponding blood levels. Radioiodinated oleic acid showed ratios between 1 and 6.5 depending on the specific activity. Insulin in 20% glucose was shown to cause substantial increases in the ratios for potassium, rubidium, cesium, and radioiodinated oleic acid. Digoxin and isoproterenol caused significant changes in myocardial clearance rates and therefore in the myocardial-to-blood ratios. The ratios for oleic acid were decreased when the compound was injected in the fasting state. The described animal model can be helpful for determining the suitability of radionuclides for myocardial scanning and for examining the effects of pharmacologic and dietary interventions.

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