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A Novel ¹²³I-Labeling Reagent. XIII. Synthesis and Loading-Dose Effects of ¹²³I-4-Iodophenylalanine and ¹²³I-5- and 6-Iodotryptophan

Brookhaven National Laboratory, Upton, New York

Correspondence: For reprints contact: Richard M. Lambrecht, Chemistry Dept., Brookhaven National Laboratory, Upton, N.Y. 11973.

ABSTRACT

A new iodination reagent—the ¹²³I species resulting from the decay of ¹²³Xe—has been used in the exchange labeling of iodinated radiopharmaceuticals in the melt. Both ¹²³14-iodophenylalanine and ¹²³I-5 and 6-iodotryptophan have been labeled by the melt method. A loading-dose effect on the ratio (percent uptake per gram) of pancreas:liver was observed in mice for ¹²³I-4-iodophenylalanine but not for ¹²³I-6-iodotryptophan.