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Comparison of ^99mTc-Polyphosphate and ¹⁸F. II. Imaging

VA Wadsworth Hospital Center and UCLA School of Medicine, Los Angeles, California

Correspondence: For reprints contact: G. T. Krishnamurthy, Nuclear Medicine Service (691/172A), VA Wadsworth Hospital Center, Los Angeles, Calif. 90073.

ABSTRACT

Comparison has been made between ^99mTc-polyphosphate (Tc-PP) and ¹⁸F in clinical imaging studies. The normal skeletal structure was better delineated with Tc-PP than with ¹⁸F. The sternum, sternoclavicular joint, iliac crests, and inferior angle of the scapulas appear more prominently with Tc-PP. The degree of renal concentration of Tc-PP seems to have good correlation with renal parenchymal function and poor correlation with ¹⁸F. In men, the scrotum and penis normally concentrate Tc-PP more avidly than ¹⁸F and so may contribute to a false-positive pelvic bone scan. Bone lesions are better delineated with Tc-PP than with ¹⁸F. A few lesions not seen with ¹⁸F are clearly delineated with Tc-PP. With Tc-PP, scintillation camera images are superior to rectilinear scans. In the scintillation camera, high-resolution collimator images are superior to high-sensitivity collimator images. Even though study time with the high-resolution collimator is relatively longer than that with the high-sensitivity collimator, the superior resolution of the high-resolution collimator more than compensates for its longer study time. It is concluded that the best skeletal images are obtained with Tc-PP and a scintillation camera equipped with a high-resolution collimator.