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Enhanced Detection of a Skeletal Lesion with Delayed ^99mTc-Polyphosphate Bone Scanning

Harvard Medical School and the Peter Bent Brigham Hospital, Boston, Massachusetts

Correspondence: For reprints contact: William D. Kaplan, Dept. of Radiology, Harvard Medical School, 25 Shattuck St., Boston, Mass. 02115.

ABSTRACT

In a patient with histologically proven neoplastic involvement of the skeleton, a ^99mTc-polyphosphate bone scan performed 5 hr after intravenous administration showed only a subtle increase in activity. At 10 hr the concentration of activity relative to background was greatly enhanced. On a subsequent ¹⁸F bone scan, there was a slight increase in activity similar to the initial (5-hr) ^99mTc-polyphosphate scan. Delayed blood clearance and/or altered uptake of the radiopharmaceutical may have played a role in the enhanced delayed images.