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Thermal and Radiolytic Decomposition of ¹³¹I-19-Iodocholesterol

University of Michigan College of Pharmacy and Division of Nuclear Medicine, Ann Arbor, Michigan

Correspondence: For reprints contact: R. D. Ice, Nuclear Medicine Div., University Hospital, University of Michigan, Ann Arbor, Mich. 48104.

ABSTRACT

Using accelerated decomposition studies, the thermal and radiolytic decomposition of ¹³¹I-19-iodocholesterol was determined. Thermal decomposition was the major cause of decomposition of ¹³¹I-19-iodocholesterol in its present formulation. Radiation decomposition does not significantly affect radiochemical purity over the expiration time of the product. A G value of 2.56 and an energy of activation of 34.6 kcal/mole was obtained with ¹³¹I-19-iodocholesterol. Radiochemical purity of 70% is obtained in 18 days if stored at 5°C and 3 days if stored at room temperature.