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Radiolanthanides as Promising Tumor Scanning Agents

School of Medicine and School of Paramedicine, Kanazawa University, Kanazawa, Japan

Correspondence: For reprints contact: Kinichi Hisada, Dept. of Nuclear Medicine, Kanazawa Univ. School of Medicine, 13-1 Takara-machi, Kanazawa-shi, Japan.

ABSTRACT

Based on the previous findings that some of the elements in the Group III and in the Period VI of the periodic table have a tumor affinity, the presence and extent of tumor affinity of radiolanthanides were examined using Yoshida sarcoma-bearing rats. Results indicated that all eight elements tested show some affinity for a tumor. Thulium-170 and ¹⁶⁹Yb are nuclides that can favorably compare with that of ⁶⁷Ga. Discovery of other good nuclides was discussed.

As a promising nuclide for clinical tumor scanning, ¹⁶⁷Tm, ¹⁶⁹Yb, and ¹⁷⁵Yb (citrate form is preferable) were suggested.