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Detection and Localization of Experimental Myocardial Infarction with ^99mTc-Tetracycline

Harvard Medical School, Boston, Massachusetts

Correspondence: For reprints contact: B. L. Holman, Dept. of Radiology, Harvard Medical School, 25 Shattuck St., Boston, Mass. 02115.

ABSTRACT

Images of myocardial infarcts were obtained with the Anger scintillation camera in five of six dogs 25 hr after coronary artery occlusion and 24 hr after the intravenous injection of ^99mTc-tetracycline. The location and size of the infarct could be accurately estimated from the scintiphotos. In vitro counting of segments from the excised heart showed that the ^99mTc-tetracycline was homogeneously distributed throughout the infarct (5.1–8.4 times greater than normal myocardium) in all six dogs, accurately delimiting the extent of infarction.

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