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Radiometric Screening Test for Chronic Granulomatous Disease

Mount Sinai School of Medicine, New York, New York

Correspondence: For reprints contact : Gerald Keusch, Div. of Infectious Disease and Laboratory of Cellular Immunology, Dept. of Medicine, Mt. Sinai Hospital, Fifth Ave. and 100th St., New York, N.Y. 10029.

ABSTRACT

A method has been developed to assay radiometrically leucocyte ¹⁴CO₂ production during phagocytosis of latex particles for the detection of chronic granulomatous disease, associated with an hereditable defect in bactericidal activity of leukocytes. Patients studied were from two affected families, with demonstration of the defect both by the radiometric assay and other methods used to measure oxidative metabolism.