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^99mTC-Polyphosphate: Histological Localization in Human Femurs by Autoradiography

Veterans Administration Hospital and University of Florida, Gainesville, Florida

Correspondence: For reprints contact: Frank H. DeLand, Nuclear Medicine Service, VA Hospital, Gainesville, Fla. 32601.

ABSTRACT

Extranuclear electrons of metastable technetium make it possible to obtain autoradiographic resolution that extends to the limits of light microscopy. Autoradiographs show the direct correlation of this scanning agent and the substructures of bone tissue. Experiments are described that are part of an effort to learn of the biological organization and fixation mechanisms for ^99mTcSnPP in bone tissue. Microautoradiography may also be used to make more precise dosimetry calculations at the cellular level. Knowledge of the quantitative and qualitative deposition of ^99mTc-polyphosphate will be of primary importance in defining the precision, sensitivity, and specificity of bone scanning with this agent.

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