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¹³¹I Thyroid Uptakes: Capsule Versus Liquid

University of California, San Diego, School of Medicine, La Jolla, California and Veterans Administration Hospital, La Jolla, California

Correspondence: For reprints contact: Samuel E. Halpern, Div. of Nuclear Medicine, University Hospital of San Diego County, 225 West Dickinson St., San Diego, Calif. 92103.

ABSTRACT

Studies were performed that indicate that normal, healthy individuals have a lower thyroidal uptake of ¹³¹I following a capsule dose of ¹³¹I than they do following a liquid dose. Two possible mechanisms for this are offered, the first being the variable amount of time it takes for the ingested capsule to dissolve completely and the second being the formation of iodine gelatin complexes in the GI tract. In the latter case, the labeled iodine would not appear to be in a form that would allow it to be trapped by the thyroid gland. It is recommended that if early uptake values are important in assessing the clinical state of the patient, liquid ¹³¹I be used in preference to capsulized ¹³¹I. Furthermore, the possibility exists that the fall in ¹³¹I uptake values noted in the past several years may in part be due to the widespread use of ¹³¹I capsules.

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