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Normalized Resin Uptake of Displaced ¹²⁵I-T₄ Using Denatured Serum

Lemuel Shattuck Hospital and Tufts University School of Medicine, Boston, Massachusetts

Correspondence: For reprints contact : Marvin Mitchell, State Laboratory Institute, Biologic Laboratories, 375 South St., Boston, Mass. 02130.

ABSTRACT

A procedure has been devised that exploits the ability of heat-denatured serum to displace ¹²⁵I-T₄ from a source of labeled thyroxine-binding protein onto a resin sponge. Heat-treated sera from pregnant women and women on oral contraceptives result in resin uptake values of displaced ¹²⁵I-T₄ that are the same as those obtained with heat-treated sera from normal controls. However, resin uptake values in hypothyroidism are significantly lower and in hyperthyroidism significantly higher than in the normal or pregnant groups. This procedure has "normalized" the behavior of sera with elevated thyroxine-binding capacities, thereby eliminating a major source of confusion seen with measurements of total thyroxine and the resin T₃ uptake.