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Measurement of Serum Thyroxine by the Tetralute® Procedure: The Effect of ¹³¹I and ^99mTc Administration

New York University School of Medicine, New York, New York

Correspondence: For reprints contact: Manfred Blum, N.Y.U. Medical Center, 560 First Ave., New York, N.Y. 10016.

ABSTRACT

Since ^99mTc and Na¹³¹I are now used quite commonly, we have frequently encountered these radionuclides in sera submitted for thyroxine (T₄) assay. Neither ^99mTc in doses of up to 10 mCi nor ¹³¹I in doses of up to 5 mCi appreciably alter serum thyroxine concentration measured by the Tetralute ®method using ¹²⁵I-labeled thyroxine.

The inorganic pertechnetate and inorganic iodide ions are effectively eliminated from the column by the first buffer wash. A small amount of ¹³¹I-labeled thyroxine is produced after therapy of thyrotoxicoses with ¹³¹I. This did not elevate total T₄ concentration significantly in the subjects studied. Gamma spectroscopy eliminated this ¹³¹I-T₄ contribution to the assay.