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Computer-Aided Statistical Analysis of the Scintillation Camera ¹³¹I-Hippuran Renogram

Michael Reese Hospital and Medical Center and the University of Chicago Pritzker School of Medicine, Chicago, Illinois

Correspondence: For reprints contact: G. Burke, Radioisotope Laboratory, Michael Reese Hospital, 29th St. and Ellis Ave., Chicago, Ill. 60616.

ABSTRACT

To Interpret objectively the scintillation camera ¹³¹I-Hippuran renogram, we used the following approach: Renal uptake of ²⁰³Hg was recorded in digital matrix form on magnetic tape; an ¹³¹I-Hippuran camera renogram was then performed and recorded as a series of 100 12-sec frames in the same matrix. A CDC 6400 computer was programmed to: (A) delineate the kidney by selecting the cells in the matrix which take up ²⁰³Hg; (B) divide each kidney into seven layers parallel to its longitudinal axis and three columns perpendicular to it; and, (C) apply these two kidney grids to the ¹³¹I-Hippuran scintillation camera renogram. These data were analyzed (A) by analysis of variance which yielded patterns indicative of specific Hippuran transit time abnormalities, and (B) by principal components factor analysis with varimax rotation, which determines within what section(s) of the kidney abnormal patterns are generated.

FOOTNOTES

^* Sorkin-Enenstein Research Service, Inc., Chicago, Ill. 60614.