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Preparation of Bolus ^99mTc-Sulfur Colloid

Veterans Administration Hospital and University of Florida College of Medicine, Gainesville, Florida

Correspondence: For reprints contact: Valerie Brookeman, Dept. of Radiology, College of Medicine, University of Florida, Gainesville. Fla. 32601.

ABSTRACT

By reducing the reagent volumes in a commercial ^99mTc-sulfur colloid kit by 75% and tagging with 0.5–1.0 ml of a highly concentrated ^99mTc solution, we have prepared ^99mTc-sulfur colloid in bolus form for dynamic liver studies. Radiochemical purity chromatographs were of excellent quality with minimal free ^99mTc. When used routinely for liver scanning, the quantity of chemical reagents administered to the patient and the cost of ^99mTc-sulfur colloid preparation were reduced by at least 75%.