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Interpretation of the ⁶⁷Ga Photoscan

National Institutes of Health, Bethesda, Maryland

Correspondence: For reprints contact: Michael S. Milder, Dept. of Nuclear Medicine, Clinical Center, Room 1B-44A, National Institutes of Health, Bethesda, Md. 20014.

ABSTRACT

Gallium-67 citrate is used to locate sites of tumor involvement throughout the body. In order to make proper use of this new agent, a knowledge of the normal ⁶⁷Ga distribution and physiological variations is necessary. For this report, over 400 whole-body rectilinear scans using 35 µCi/kg ⁶⁷Ga citrate were reviewed. At 48 hr, normal ⁶⁷Ga activity is concentrated in the axial skeleton, liver, spleen, and around the large joints. Foci of uptake are often seen in the salivary, lacrimal, and mammary glands. Activity is also found in the region of the nasopharynx. Under certain physiological conditions, intense localisation may occur within the breast, bowel, and long bones. These variations may mimic malignant tumors. Lymph nodes involved by malignant disease present a distinctive pattern that aids in their identification.