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Technetium-99m-Labeled Stannous Ethane-1-Hydroxy-11-Diphosphonate: A New Bone Scanning Agent

Donner Laboratory and Lawrence Berkeley Laboratory, University of California, Berkeley, California

Correspondence: For reprints contact: Yukio Yano, Donner Laboratory, Lawrence Berkeley Laboratory, University of California, Berkeley, Calif. 94720.

ABSTRACT

Technetium-99m was complexed with Sn-EHDP to provide a bone scanning agent that makes available the superior scanning characteristics of ^99mTc. The concentrations of Sn(II) and EHDP as well as the order of addition of the reagents influence the in vivo distribution of the ^99mTc-Sn-EHDP. In vitro stability was dependent upon having oxygen-free environment for the preparation. Animal studies and human studies now in progress indicate that ^99mTc-Sn-EHDP will be extremely useful as a bone scanning agent because of the high ratio of bone-to-soft tissue uptake, high lesion-to-normal-bone uptake, rapid disappearance from blood and soft tissues, and low radiation dose to the patient.