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The Journal of Nuclear Medicine Vol. 14 No. 11 816-819
© 1973 by Society of Nuclear Medicine
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Measurement of 127I Concentration in Thyroid Tissue by X-Ray Fluorescence

Adrian D. LeBlanc, Robert L. Bell* and Philip C. Johnson

The Methodist Hospital and Baylor College of Medicine, Houston, Texas

Correspondence: For reprints contact: Adrian LeBlanc, Dept. of Internal Medicine, Baylor College of Medicine, Texas Medical Center, Houston, Tex. 77025.

ABSTRACT

X-ray fluorescence was used to determine the iodine content of surgically removed thyroids which had been preoperatively scanned with 131I. Iodine concentrations were determined for tissues classified as normal, papillary-follicular carcinoma, chronic thyroiditis, and colloid nodules of adenomatous thyroids. The iodine concentration of these thyroid states varied, with carcinomatous tissue having the lowest concentration and normal tissue the highest. There was considerable overlap among the various pathological states. Nodules showing increased 131I activity on the presurgical thyroid scan contained no more iodide than normal tissue, while nodules showing decreased 131I activity contained considerably less iodine. The residual 131I from the presurgical dose showed a distribution similar to the distribution of stable iodine.

The iodine concentration of normal thyroid tissue obtained from autopsy specimens was determined to be about 2.5 times greater than the levels reported in the older literature.

FOOTNOTES

* Present address: 230 Twenty-Fifth Ave. N., Post Office Box 70, Nashville, Tenn. 37203.






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Copyright © 1973 by the Society of Nuclear Medicine.