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Chromatographic Quality Control of ^99mTc-Labeled Compounds

Winnipeg General Hospital, Winnipeg, Manitoba, Canada

Correspondence: For reprints contact: M. W. Billinghurst, Section of Nuclear Medicine, Health Sciences Center, 700 Willow Ave., Winnipeg, Manitoba, Canada.

ABSTRACT

The increasingly general use of a number of ^99mTc-labeled compounds makes the need for an understanding of the capabilities of simple quality-control procedures urgent. A number of ^99mTc radiopharmaceuticals which are already in general use have been studied in various chromatographic procedures which might potentially provide adequate quality control. The comparative effectiveness of each of these chromatographic procedures for the accurate quality control of each radiopharmaceutical may be readily observed and an adequate procedure decided upon. The practical ease of handling and the technical skills necessary for the accurate handling of each chromatographic system is discussed. It is recommended that quality control of ^99mTc-albumin be done on a Sephadex G50 column and that of ^99mTc-DTPA be done with thin-layer silica gel chromatography in both saline and acetone or butyl acetate. The quality-control procedure for ^99mTc-polyphosphate is shown to be dependent on the commercial kit which is used. Two such commercial kits are discussed.

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