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Labeled Dopamine Concentration in Pheochromocytomas

University of Michigan Medical Center, Ann Arbor, Michigan

Correspondence: For reprints contact: William H. Beierwaltes, Nuclear Medicine Div., University of Michigan Medical Center, Ann Arbor, Mich. 48104.

ABSTRACT

Carbon-14-dopamine was injected intraveously into two patients who had three pheochromocytomas removed. The operations were performed about 1, 2, and 8 hr after injection of the tracer dose. The concentration of ¹⁴C radio activity was higher in the tumors removed at 2 hr and at 8 hr than at 1 hr after the tracer dose. The tumors contained 0.09–0.6% of the administered radioactivity. The ¹⁴C-dopamine and ¹⁴C-norepinephrine content of the tumors was determined. Almost all of the radioactivity was found in the norepinephrine fraction at all time intervals tested.