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Potential Organ or Tumor-Imaging Agents. 12. Esters of 19-Radioiodinated Cholesterol

The University of Michigan, Ann Arbor, Michigan

Correspondence: For reprints contact: R. E. Counsell, Laboratory of Medicinal Chemistry, College of Pharmacy, The University of Michigan, Ann Arbor, Mich. 48104.

ABSTRACT

The acetate and palmitate esters of ¹²⁵I-19-iodocholesterol were synthesized for tissue distribution studies in rats. Tissues were analyzed at 48 and 96 hr after intravenous, subcutaneous, and oral administration. In contrast to ¹²⁵I-19-iodocholesterol, the esters failed to show appreciable adrenal uptake following intravenous or subcutaneous administration. All forms, however, produced significant radioactivity in the adrenals when given orally. In fact, the best adrenal-to-liver ratio was achieved by this route. These results imply that esters of 19-radioiodinated cholesterol can serve as substrates for pancreatic cholesterol esterase and suggests their possible use in the diagnosis of pancreatic in sufficiency.