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Usefulness of Computer Scintigraphy for Detecting Liver Tumor with ⁶⁷Ga-Citrate and the Scintillation Camera

Kyoto University School of Medicine, Kyoto, Japan

Correspondence: For reprints contact: Ken Hamamoto, The Central Clinical Radioisotope Div., Kyoto University School of Medicine, Sakyo-ku, Kyoto, Japan.

ABSTRACT

The usefulness of scintiphotography, particularly computer scintigraphy using ⁶⁷Ga-citrate and the scintillation camera for detecting the tumors of the liver, was evaluated.

Twenty-nine patients with liver tumors were examined by the scintillation camera coupled to a 1,600-channel analyzer and tape data storage for computer processing using ⁶⁷Ga-citrate, ¹⁹⁸Au-colloid, and ¹³¹I-BSP.

Gallium-67 administered as the citrate was excreted into the bowel and distributed within the normal liver tissue. This made it difficult to delineate the tumor image in the liver. The dual isotopes, ⁶⁷Ga-citrate and ¹⁹⁸Au-colloid (or ¹³¹I-BSP), allowed computer-subtraction scintigraphy to be applied which enabled us to delineate the tumor image in two cases with metastatic liver tumor invisible on conventional scintiphotography with these isotopes.

These results suggested that ⁶⁷Ga-citrate scintigraphy, particularly computer scintigraphy, was clinically useful in evaluating the presence and distribution of tumors of the liver.