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Renal Imaging in Humans with the Technetium-Labeled Polypeptide, Caseidin

Donner Laboratory, University of California, Berkeley, California
Kaiser Foundation Hospital, Oakland, California

Correspondence: For reprints contact: Max S. Lin, Div. of Endocrinology and Nuclear Medicine, Michael Reese Hospital and Medical Center, Chicago, Ill. 60616.

ABSTRACT

Trial in 20 patients with a ^99mTc-labeled polypeptide, caseidin, has shown it to be an effective agent for renal imaging in humans. It was found to concentrate in the cortex of functioning kidneys following intravenous administration. The concentration was prompt, sustained, and high enough to allow dose-to-imaging intervals as short as 5 min, ample time for multiple imaging, and practical use of a small pinhole collimator for improved resolution in the imaging of kidneys.

No adverse effects from the administration of this material was encountered in this limited trial study. Definitive evaluation of the safety of this effective renal imaging agent requires further study.