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Albumin Microspheres for Study of the Reticuloendothelial System

The Johns Hopkins Medical Institutions, Baltimore, Maryland

Correspondence: For reprints contact: Ursula Scheffel, Dept. of Radiological Science, The Johns Hopkins Medical Institutions, 615 North Wolfe St., Baltimore, Md. 21205.

ABSTRACT

An improved method for the preparation of HSA microspheres with an average diameter of 0.5–0.7 microns and narrow particle-size range, suitable for the study of the RES, has been described. No toxic effects towards the new drug were observed in animals. Nonradioactive HSA spheres could be stored for more than 10 months. Labeling of the spheres with ^99mTc was carried out under sterile conditions immediately before use. The tagging efficiency was 65–83%, and the labeled product was stable for up to 20 hr. When injected intravenously, about 90% of the ^99mTc microspheres were extracted by the liver. Blood clearance studies in dogs showed small variability in day-to-day preparations. The advantage of this new drug over the widely used ^99mTc-sulfur-colloid is that it can be used for the assessment of RES functions in addition to scanning the distribution of the RES.

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