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Uptake of ¹³N-Labeled Ammonia

Sloan-Kettering Institute for Cancer Research, New York, New York

Correspondence: For reprints contact: John S. Laughlin, Div. of Biophysics, Sloan-Kettering Institute for Cancer Research, New York, N.Y. 10021.

ABSTRACT

A method has been developed for the production of ¹³N-labeled ammonia in usable quantities with negligible contamination. Studies in dogs have characterized the uptake and clearance rates of the labeled compound in myocardium, liver, and kidney. The early metabolic pathway of ammonia is not known but can now be more readily studied. This includes studies of the possibility of synthesis leading to the amide group of glutamine which can be incorporated into purine nucleotides and to carbamoyl phosphate and urea. This radioactive pharmaceutical appears to be a promising myocardial scanning agent with an excellent information to radiation dose ratio. It should also be useful for kidney and liver function studies and has potential as a soft-tissue tumor scanning agent.

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