HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Lambrecht, R. M. Articles by Wolf, A. P. Search for Related Content PubMed PubMed Citation Articles by Lambrecht, R. M. Articles by Wolf, A. P.

Preparation of High-Purity Carrier-Free ¹²³I-Iodine Monochloride as Iodination Reagent for Synthesis of Radiopharmaceuticals, IV

Brookhaven National Laboratory, Upton, New York

Correspondence: For reprints contact: Richard M. Lambrecht, Chemistry Dept., Brookhaven National Laboratory, Upton, N.Y. 11973.

ABSTRACT

The ¹²²Te(⁴He,3n)¹²³Xe
¹²³I nuclear transformations and a silver scrubber produce ¹²³I in greater than 99.8% radionuclide purity. The ¹²³I has been incorporated into several model radiopharmaceuticals by use of ¹²³ICl as the iodination reagent. The parameters affecting the synthesis of ¹²³ICl as a result of the Auger cascade and the coulombic explosion associated with the ¹²³Xe decay in mixtures of ICl, Cl₂ and NOCl are reported. The influence of pressure, the effects of additives, as well as the use of ¹²³ ICl as an iodination reagent are discussed and compared with other methods of iodination of radiopharmaceuticals.

FOOTNOTES

^* Visiting scientist during 1971 from Institute of Atomic Physics, P.O. Box 35, Bucharest, Romania.