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^99mTc-EHDP: A Potential Radiopharmaceutical for Skeletal Imaging

Upstate Medical Center, Syracuse, New York

Correspondence: For reprints contact: Gopal Subramanian, Div. of Nuclear Medicine, Dept. of Radiology, Upstate Medical Center, Syracuse, N.Y. 13210.

ABSTRACT

Excellent skeletal images have been obtained with ^99mTc-EHDP in animals. Its skeletal concentration is comparable to ^99mTc polyphosphates. It has the advantage of a more rapid blood clearance, and relatively lower soft tissue concentrations. However, it is apparently not biodegradable. More information must be obtained about its intravenous toxicity and biological fate before it can be considered for trial in humans. It is likely that other diphosphonates like MDP, Cl₂MDP, and EHDP condensate, labeled with ^99mTc, will also exhibit good skeletal localization. Further work along these lines is in progress.

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