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Macroaggregation of an Albumin-Stabilized Technetium-Tin(II) Colloid

Donner Laboratory, University of California, Berkeley, California

Correspondence: For reprints contact: H. Saul Winchell, Donner Laboratory, Univ. of California, Berkeley, Calif. 94720.

ABSTRACT

A rapid two-staged method was described for converting a technetium-tin(II) colloid stabilized with albumin into a technetium-labeled macroaggregate. In the first stage of the method, the colloid was heated to convert it into a suspension of oversize aggregates. In the second stage, the oversize aggregate was forcefully disrupted into fragments, and those fragments still exceeding 150 microns were removed with a sieve.

The macroaggregate prepared by this method has a controlled upper limit of the particle size, a low content of free or colloidal technetium, and a reasonable stability in vitro and degradability in vivo.