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Regional Cerebral Blood Flow with the Anger Camera

Edward E. Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, Missouri

Correspondence: For reprints contact: B. L. Holman, Dept. of Radiology, Harvard Medical School, 25 Shattuck St., Boston, Mass. 02115.

ABSTRACT

Regional cerebral blood flow was quantified with the Anger camera after the intra-arterial injection of ¹³³Xe. The camera crystal was electronically divided into an 8 x 8 array and interfaced to a programmed console computer for data accumulation. Stochastic analysis (H/A) was used for calculating the regional blood flows because (A) the computer program is relatively simple and (B) a number of biological assumptions required in compartmental analysis need not be made in stochastic analysis.

Five angiographically normal patients were studied. The average hemispheric flows ranged from 43.3 to 60.2 with a mean of 50.5 cc/min/ 100 gm. These values are similar to the normal values reported with other techniques.

Regional differences in cerebral blood flow were found in each patient. The flow over the convexity averaged 18.9% higher than the midportion of the hemisphere, and the flow at the base averaged 7.1% lower than the midportion.

The Anger camera is an accurate external detector for measuring regional blood flow with inert gas washout techniques provided that standard deadtime corrections are performed. Stochastic analysis enabled us to use a relatively simple computer program so that data could be accumulated and processed on a small general purpose computer. The biological data were similar to that obtained with multiple probes. In addition, regional differences in cerebral blood flow were found with the Anger camera system which have not been described with multiple probe systems.