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Evaluation of Technetium-Labeled Red Cells for Determination of Red Cell Volume in Man

The Johns Hopkins Medical Institutions, Baltimore, Maryland

Correspondence: For reprints contact: Patricia A. McIntyre, 615 N. Wolfe St., Baltimore, Md. 21205.

ABSTRACT

The method described by Eckelman, et al (7) of using ^99mTc with a small amount of stannous chloride to label erythrocytes has been evaluated as a method of providing erythrocytes labeled with a short-lived gamma-emitting nuclide for measuring red cell mass in man. Eighteen patients had simultaneous measurements of red cell mass with ⁵¹Cr-labeled erythrocytes and ^99mTc-labeled erythrocytes. In each instance, the results given by the two methods were nearly identical, when the time period of observation was limited to 30 min after injection of the labeled cells. Thereafter, the technetium label seems to distribute progressively in a slightly larger space than the ⁵¹Cr label. Technetium-99m-labeled erythrocytes offer a satisfactory agent for the measurement of red cell mass with the advantages over the ⁵¹Cr method of facilitating repeated measurements in given individuals and reducing the radiation dose to the subject.