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Effects of Radiation Therapy on Bone Lesions as Measured by ⁴⁷Ca and ⁸⁵Sr Local Kinetics

Sloan-Kettering Institute for Cancer Research and Memorial Hospital, New York, New York

Correspondence: For reprints contact: Ernest Greenberg, Memorial Hospital for Cancer and Allied Diseases, New York, New York 10021.

ABSTRACT

A study was carried out to investigate the sequential changes of uptake and retention of ⁴⁷Ca and ⁸⁵Sr after radiation therapy of malignant bone lesions and to correlate these changes with clinical symptoms and roentgenographic findings. Eight patients with bone metastases from breast carcinoma and one patient with primary reticulum cell sarcoma of the bone were studied. Calcium-47 given prior to radiotherapy and at intervals of 1–4 months afterward served to measure the changes in uptake of mineral by bone over a 1-year period. A single dose of ⁸⁵Sr given prior to therapy as a labeling dose to the skeleton was measured at similar intervals as an index of the rate of loss of mineral bone.

The majority of patients exhibited a rise in ⁴⁷Ca uptake by tumor-involved bone 1–2 months after radiation therapy, followed by a gradual fall. A relative increase of ⁸⁵Sr retention in the irradiated bone was observed and these two processes of increased uptake and higher retention of minerals lead to a recalcification of previously destructive lesions. Practically all the patients experienced a relief of pain and showed radiographic evidence of recalcification.

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