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Significance of ¹⁸F-Fluoride Renal Accumulation during Bone Imaging

Northwestern University Medical School and Chicago Wesley Memorial Hospital, Chicago, Illinois

Correspondence: For reprints contact: Shyam M. Sharma, Chicago Wesley Memorial Hospital, 250 E. Superior St., Chicago, Ill. 60611.

ABSTRACT

Fluorine-18-fluoride bone scans performed on 160 consecutive patients were examined in retrospect to study the incidence and extent of ¹⁸F accumulation in the kidneys. Pointers in clinical history and laboratory studies indicative of renal function and morphology were available from the hospital notes in 27 patients and were correlated to the degree and equality of ¹⁸F renal concentration on the scans.

The following conclusions were made from the study:

1. Restriction of fluids for about 4 hr before injection of ¹⁸F-fluoride resulted in absent or slight ¹⁸F renal radioactivity in two-thirds of the patients, which would have otherwise interfered with the bone scan interpretation of the lumbar region.

2. Absence of ¹⁸F concentration in the kidneys does not preclude renal disease.

3. The degree of ¹⁸F concentration bears no relation to kidney disease.

4. A large majority of patients (84.6%) with unequal ¹⁸F concentration in the kidneys showed unilateral renal abnormalities. None of the patients with equal concentration showed renal disease.

5 It was not possible to predict which of the two kidneys was involved in patients with unequal concentration of ¹⁸F.