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Tissue Distribution of ¹²⁵I-Toluidine Blue in the Rat

Edward Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, Missouri

Correspondence: For reprints contact: Ellen G. Archer, Dept. of Biology, University of Missouri at St. Louis, 8001 Natural Bridge Rd., St. Louis, Mo. 63121.

ABSTRACT

Iodine-125-toluidine blue was prepared from toluidine blue and Na¹²⁵I and purified by solvent extraction. The ¹²⁵I-toluidine blue was found to be chromatographically pure and to behave similarly to unlabeled toluidine blue in rat tissues. Uptake of toluidine blue by parathyroid glands 5 min after intravenous injection was twice that by pancreas and three times that by thyroid. After 15 min, uptake by parathyroid tissue had fallen to levels as low or lower than those of pancreas and thyroid in which uptake had also declined. Uptake of toluidine blue by heart muscle at 15 min after intravenous injection was 1 times that in stomach, twice that in pancreas and thyroid, and six times that in liver and skeletal muscle. Parathyroid uptake of ¹²⁵I-toluidine blue was not increased in rats which had been fed a low-calcium diet while uptake of ⁷⁵Se-selenomethionine was increased.