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^99mTc-Penicillamine-Acetazolamide Complex, a New Renal Scanning Agent

Wadsworth Veterans Hospital, Los Angeles, California
University of California at San Diego, San Diego, California

Correspondence: For reprints contact: Samuel E. Halpern, Div. of Nuclear Medicine, University Hospital, 225 W. Dickinson St., San Diego, Calif. 92103.

ABSTRACT

Technetium-99m-penicillamine-acetazolamide complex (TPAC), a new renal scanning agent, is prepared by the reduction of pertechnetate by penicillamine followed by complexing of this compound with acetazolamide. Plasma half-time disappearance of the compound ranges from 45 to 60 min in a dog with normal kidneys. If the kidneys are excluded from the circulation, half-time disappearance is prolonged to 90 min. TPAC is 97% protein bound to all classes of plasma proteins, the majority, however, being associated with the albumin fraction. Minute amounts are removed from the circulation by the kidney by either glomerular filtration and tubular reabsorption or by tubular extraction and delayed excretion. Outstanding scan images can be obtained in patients with very severe renal disease.