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Erythrocytic Production in Anemias. I. The Use of the Survival Curve for Estimating Production in the Nonsteady State

Instituto Nacional de la Nutrición, Mexico City, Mexico

E. Juárez-Badillo

Universidad Nacional Autónoma de Mexico, Mexico City, Mexico

Correspondence: For reprints contact: Luis Sánchez-Medal, Division de Medicina, Instituto Nacional de la Nutrición, Viaducto Tlalpan y Av. San Fernando, Mexico 22, D.F.

ABSTRACT

The paper gives the basis and the mathematical formulation needed to measure erythrocytic production and destruction in some situations in which a nonsteady state of erythropoiesis is present. To obtain quantitative data on the kinetics of erythropoiesis during the lapse of study, the equations demand basically two or more red cell volume estimations associated with the changes in the concentration of labeled cells per milliliter of cells occurring during the time that elapses between each pair of red cell volume estimations. The approach is applicable to cases in which the cell loss is due mainly to a single mechanism of destruction, either senescence or random.