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Evaluation of ^99mTc-DTPA for the Measurement of Glomerular Filtration Rate

Brookhaven National Laboratory, Upton, New York

Correspondence: For reprints contact: Harold L. Atkins, Medical Dept. Brookhaven National Laboratory, Upton, N.Y. 11973.

ABSTRACT

The usefulness of ^99mTc-DTPA as an agent for measuring glomerular filtration rate was evaluated in five dogs and 11 human patients. In dogs, using a constant infusion technique, no change in ^99mTc-DTPA clearance was found at different urine flow rates or following tubular blockade with probenecid. In the patients clearance of ^99mTc-DTPA was 8% lower than that of ¹²⁵I-iothalamate as determined by single-injection technique. The two compounds, however, had similar rates of plasma disappearance and urinary excretion. Thus ^99mTc-DTPA, rapidly prepared by a kit method, is a useful addition to the list of radiopharmaceuticals that can be used for measurement of GFR.

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