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Uptake of Radioiodinated Human Chorionic Gonadotropic Hormone by Ovarian Carcinoma

University of Michigan Medical Center and Veterans Administration Hospital, Ann Arbor, Michigan

Correspondence: For reprints contact: William H. Beierwaltes, Nuclear Medicine Div., University Hospital, University of Michigan Medical Center, Ann Arbor, Mich. 48104.

ABSTRACT

Iodine-125-HCG was administered to ten female and nine male mice and tissue-to-blood ratios were studied 3 hr later at sacrifice. The mean ovary-to-blood ratio was 4.5. The ovarian concentration of ¹²⁵I was 8–12 times greater than that in all other tissues studied, except the kidney. The kidney-to-blood ratio of 1.5–2.5 presumably was related to the excretory function of this organ. The ¹²⁵I-HGH given to seven female mice showed no concentration in the ovary at 3 hr. Ovarian theca cell tumors in eight mice concentrated ¹²⁵I-HCG in similar amounts to that of normal ovaries. Ovarian granulosa cell tumors in nine mice did not concentrate ¹²⁵I-HCG. The ¹²⁵I-HGH did not concentrate in ovarian theca cell tumors in four mice.

Female monkeys given ¹²⁵I-HCG and sacrificed one each at 1, 2, 2.5, 3, and 5 hr, showed a maximum uptake of ¹²⁵I at 2 hr with an ovary-to-blood ratio of 1.2, 2–12 times greater than the uptake in nonovarian and renal tissues. Autoradiography showed the radioactivity to be concentrated in the theca layers of the follicles and in the interstitium, and in the theca cell cytoplasm of theca tumors.